Regulatory mechanisms of sterol transporters under pathophysiological conditions

已知Niemann-Pick C1-like 1 （NPC1L1）有助于小肠和肝脏的胆固醇吸收，并被认为是依折替米贝的药理学靶点。本研究成功构建了人类NPC1L1启动子驱动的腺病毒，用于表达人类NPC1L1。此外，研究表明L-FABP以转录后的方式参与了NPC1L1蛋白表达的正向调节。这些结果对于理解肥胖相关疾病的发病机制与胆固醇转运蛋白之间的关系具有重要意义。

Niemann-Pick C1-like 1 (NPC1L1) is known to contribute to the cholesterol absorption in the small intestine and liver and is believed to be a pharmacological target of ezetimibe. As a result of the present study, we succeeded in the construction of human NPC1L1 promoter-driven adenovirus for the expression of human NPC1L1. In addition, it was demonstrated that L-FABP is involved in the positive regulation of the expression of NPC1L1 protein in a post-transcriptional manner. These results would be important to understand the relationship between the pathogenesis of obesity-related diseases and sterol transporters.