Inter-individual variations of flavin-containing monooxygenase 3 levels associated with multiple regulation factors
Inter-individual variations of flavin-containing monooxygenase 3 levels associated with multiple regulation factors
批准号:
21790160
负责人:
SHIMIZU Makiko
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
含黄素单加氧酶3(FMO3)催化多种含硫或氮原子的化合物的氧化。FMO3在处理一些药物、成瘾性化学尼古丁和饮食衍生的三甲胺中起作用。FMO3基因的个体间变异可能受FMO3基因反式作用因子的共同调控。
英文摘要
The flavin-containing monooxygenase 3 (FMO3) catalyzes the oxygenation of a wide variety of compounds containing sulfur or nitrogen atoms. FMO3 plays a role in processing some drugs, addictive chemical nicotine and diet-derived trimethylamine. Inter-individual variations of FMO3 are suggested to be co-regulated by trans-acting factors of FMO3 gene.
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喫煙者血中濃度領域でのニコチン酸化的代謝に関与する薬物代謝酵素
吸烟者血药浓度范围内参与尼古丁氧化代谢的药物代谢酶
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[永野卓, 清水万紀子, 村山典恵, 山崎浩史]
通讯作者:
山崎浩史
Cytochrome P450-dependent drug oxidation activity of liver microsomes from Microminipigs, a possible new animal model for humans in non-clinical studies.
来自微型猪的肝微粒体的细胞色素 P450 依赖性药物氧化活性,微型猪是人类非临床研究中可能的新动物模型。
DOI:
--
发表时间:
2009
期刊:
Drug Metab Pharmacokinet. 24(4)
影响因子:
--
作者:
[Murayama N, Kaneko N, Horiuchi K, Ohyama K, Shimizu M, Ito K, Yamazaki H.]
通讯作者:
Yamazaki H.
Bonitos as palliative care for Japanese trimethylaminuria subjects
鲣鱼作为日本三甲胺尿症患者的姑息治疗
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Makiko Shimizu, Marie Kozono, Norie Murayama, Hiroshi Yamazaki]
通讯作者:
Hiroshi Yamazaki
タバコ煙曝露量予測のための日本人喫煙者バイオモニタリング
对日本吸烟者进行生物监测以预测烟草烟雾暴露
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[永野卓, 清水万紀子, 堀内佳奈, 村山典恵, 庄野文章, 山崎浩史]
通讯作者:
山崎浩史
Bonitos with low content of malodorous trimethylamine as palliative care for self-reoorted Jananese trimethvlaminuria subiects.
恶臭三甲胺含量低的鲣鱼作为自我报告的日本三甲胺尿症患者的姑息治疗。
DOI:
--
发表时间:
2009
期刊:
Drug Metab Pharmacokinet. 24(6)
影响因子:
--
作者:
[Shimizu M, Kozono M, Murayama N, Yamazaki H.]
通讯作者:
Yamazaki H.
共 20 条
Pharmacokinetics prediction of drugs in humans associated with flavin-containing monooxygenase dependent-oxygenations in livers and kidneys of animal models
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批准号:16K08380
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
-
财政年份:2016
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负责人:SHIMIZU Makiko
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依托单位:
Drug oxygenations and interactions mediated by polymorphic flavin-containing monooxygenases
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批准号:25460198
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2013
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负责人:SHIMIZU Makiko
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依托单位:
Developmental variations in metabolic capacity of flavin-containing monooxygenase 3 in childhood
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批准号:23790200
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.83万
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财政年份:2011
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负责人:SHIMIZU Makiko
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依托单位:
The function of law and other social norms: case of goods transport in Japan
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批准号:21653006
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.77万
-
财政年份:2009
-
负责人:SHIMIZU Makiko
-
依托单位:
Interindividual variations of flavin-containing monooxygenase 3 (FMO3) related to menstruation
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批准号:19790134
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.28万
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财政年份:2007
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负责人:SHIMIZU Makiko
-
依托单位:
海外基金