The role of NMDA receptor/PSD-95/SPAL-1/Rap signaling in higher brain function

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In this study, we carried out a series of electrophysiological recordings with a focus on CA1 and CA3 regions in hippocampal slices from SPAL-1 KO mice. Most of the electrophysiological properties of the CA1 were normal. However, we found mossy fiber LTP recorded in CA3 region was significantly impaired. Furthermore, we found that phospholylation of p42/44 MAPK is significantly reduced in the stratum lucidum of CA3. Our study may contribute to the elucidation of the novel mechanism of mossy fiber LTP.