Mechanisms of colon cancer stem cell self-renewal and pluripotency
Mechanisms of colon cancer stem cell self-renewal and pluripotency
批准号:
23689019
负责人:
KAWASAKI Yoshihiro
金额:
$17.89万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (A)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Cancer stem cells are thought to be responsible for both metastasis and cancer recurrence. We utilized FACS sorting to isolate cancer stem cells (CSCs) and non-cancer stem cells from xenograft human colon tumors to analyze gene expression. RNA-seq analysis revealed that 374 genes were significantly up-regulated in CSCs. Furthermore, we found that knockdown of any of 13 genes resulted in decreased growth ofCSCs. Hereafter, we will investigate the importance of these genes in CSC behavior.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
miR-1-Notch3-Asef経路は大腸癌細胞の運動能亢進に重要である
miR-1-Notch3-Asef 通路对于结直肠癌细胞的过度运动很重要
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Matsuoka S, Takeuchi A(edited by Okada Y), 川崎善博・古川史織・秋山徹]
通讯作者:
川崎善博・古川史織・秋山徹
癌抑制遺伝子産物APCの機能解析
抑癌基因产物APC的功能分析
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H, 川崎善博・秋山徹]
通讯作者:
川崎善博・秋山徹
Differences in the localization of the APC-Asef/Asef2 complex between APC wild-type and mutant cells
APC 野生型和突变细胞之间 APC-Asef/Asef2 复合物定位的差异
DOI:
10.1111/cas.12180
发表时间:
2013
期刊:
Cancer Sci.
影响因子:
--
作者:
[Yoshihiro Kawasaki, Shiori Furukawa, Rina Sato, Tetsu Akiyama]
通讯作者:
Tetsu Akiyama
The role of NMDA receptor/PSD-95/SPAL-1/Rap signaling in higher brain function
-
批准号:21790265
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.75万
-
财政年份:2009
-
负责人:KAWASAKI Yoshihiro
-
依托单位:
Functional analysis of APC in neurite outgrowth
-
批准号:19770162
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.41万
-
财政年份:2007
-
负责人:KAWASAKI Yoshihiro
-
依托单位:
海外基金