A functional analysis of HIF for tumor metastasis

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VCAM-1 function was suggested that important for early metastasis foci formation. VCAM-1 expression reduced in HIF-2α knockdown mice. These results suggested that HIF-2α participate in metastasis via regulation of VCAM-1 expression. We analyzed by metastasis model in vivo. It number of the liver metastasis foci of HIF-2α kd was reduced than WT (WT : 5.0±1.0/field, HIF-2α kd : 2.8±0.76/field).