Analysis of the effects of hypoxia inducible factor for tumor metastasis

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Hypoxia inducible transcription factor (HIF) has various physiological functions. The results of the HIF functional analysis in vascular endothelial cells with tail vein injection metastasis model, we found that metastasis foci was reduced when transplanted into HIF-2alpah knockdown host mice. HIF-2alpa knockdown mice have low activities in HIF-2alpha in endothelial cells. Furthemore, HIF-3alpha acting on inhibitory to the hypoxic response is controlling to the inhibitory VE-cadherin expression in pulmonary vascular endothelial cells. We found the phenomenon that HIF-1apha is activated in compensatory when HIF-2alpha was reduced to a certain level below threshold.