Molecular-biological analysis and differential diagnosis in epithelioid sarcoma and malignant rhabdoid tumor

上皮样肉瘤（ES）和恶性横纹肌样肿瘤（MRT）在microRNA谱方面被认为是不同的肿瘤实体。同时，SMARCB1/INI1蛋白表达缺失的儿童未分化肉瘤，形态类似恶性淋巴瘤，可能具有与MRT相同的谱。glypican 3（GPC3）免疫表达的评估可能是一个有用的诊断工具，以区分ES和MRT。提示glypican 3过表达的MRTs可能成为GPC3免疫治疗的新靶点。

Epithelioid sarcoma(ES) and malignant rhabdoid tumor(MRT) are suggested to be distinct tumor entities with respect to the microRNA profiles. Meanwhile, pediatric undifferentiated sarcoma with loss of SMARCB1/INI1 protein expression, morphologically resembling malignant lymphoma, may have the same spectrum as MRT. Evaluation of glypican 3(GPC3) immunoexpression may be a useful diagnostic tool to distinguish ES from MRT. It is suggested that MRTs with glypican 3 overexpression may become a new target of GPC3 immunotherapy.