Re-classification for therapeutic application in SMARCB1/INI1 deficient tumors

SMARCB1/INI1 缺陷肿瘤的治疗应用重新分类

• 批准号: 24790352
• 负责人: KOHASHI Kenichi
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790352/
• 关键词: 悪性ラブドイド腫瘍; 類上皮肉腫; SMARCB1/INI1; Akt-mTOR; Akt-mTOR経路

Pediatric SMARCB1/INI1 (INI1)-deficient tumors were able to be re-classified into the three groups: conventional type, atypical teratoid/rhabdoid (AT/R) type and small cell type. Activation in Akt-mTOR pathway was found more frequently in AT/R and small cell types than in conventional type. Meanwhile, in most cases of epithelioid sarcoma (ES) including both conventional and proximal types, the Akt-mTOR pathway was activated.It is suggested that mTOR inhibition is a potential treatment option for AT/R and small cell types of pediatric INI1-deficient tumor and ES. ES and malignant rhabdoid tumor are suggested to be distinct tumor entities.

儿童SMARCB1/INI1(INI1)缺陷型肿瘤可重新分为三组：常规型、不典型畸胎样/横纹肌样(AT/R)型和小细胞型。在AT/R和小细胞型中，Akt-mTOR通路的激活频率高于常规型。同时，在大多数上皮样肉瘤(ES)中，包括常规型和近侧型，Akt-mTOR通路都被激活。提示mTOR抑制是一种潜在的治疗儿童AT/R和小细胞型INI1缺陷肿瘤和ES的方法。ES和恶性横纹肌样瘤被认为是不同的肿瘤实体。

项目成果

類上皮肉腫におけるAkt/mTOR経路関連蛋白の発現検討

Akt/mTOR 通路相关蛋白在上皮样肉瘤中的表达

• 发表时间: 2013
• 作者: 孝橋賢一;髙橋祐介;山田裕一;石井武彰;井浦国生;前川啓;山元英崇;岩本幸英;小田義直
• 通讯作者: 小田義直

An augmented reality navigation system for pediatric oncologic surgery based on preoperative CT and MRI images.

• DOI: 10.1016/j.jpedsurg.2013.08.025
• 发表时间: 2013-12
• 期刊: Journal of pediatric surgery
• 影响因子: 2.4
• 作者: R. Souzaki;S. Ieiri;M. Uemura;K. Ohuchida;M. Tomikawa;Y. Kinoshita;Yuhki Koga;A. Suminoe;Kenichi Kohashi;Y. Oda;T. Hara;M. Hashizume;T. Taguchi

A morphological study of the removed livers from patients receiving living donor liver transplantation for adult biliary atresia

• DOI: 10.1007/s00383-012-3183-6
• 发表时间: 2012-12-01
• 期刊: PEDIATRIC SURGERY INTERNATIONAL
• 影响因子: 1.8
• 作者: Matsuura, Toshiharu;Kohashi, Kenichi;Taguchi, Tomoaki
• 通讯作者: Taguchi, Tomoaki

小児軟部腫瘍

小儿软组织肿瘤

• 发表时间: 2013
• 作者: 孝橋賢一;山元英崇;山田裕一;小田義直
• 通讯作者: 小田義直

Art-mTOR pathway Activation Analysis in Re-Classified Prediatric

重新分类的幼儿期的 Art-mTOR 通路激活分析

• 发表时间: 2013
• 作者: Kohashi K;Endo M;Setsu N;Takahashi Y;Yamada Y;Yamamoto H;Oda Y
• 通讯作者: Oda Y