Role of the specific chimeric oncogene in the pathology of alveolar soft part sarcoma

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Alveolar soft part sarcoma contains specific chimeric oncogene ASPL-TFE3, which has been thought to play a crucial role in the onset and progression of alveolar soft part sarcoma. In this study, the candidate genes whose expression is regulated by ASPL-TFE3 were investigated by using DNA microarray analysis. In response to ASPL-TFE3 expression, we found that 739 genes were up-regulated at least 2-fold higher than in untreated cells, and 169 genes were down-regulated at least 0. 5-fold lower than in untreated cells. Transcriptional targets of ASPL-TFE3 include metabolic genes, cell proliferation genes, apoptotic genes and signal transduction genes. These results suggest that ASPL-TFE3 contribute to oncogenesis and pathology of alveolar soft part sarcoma by inducing the aberrant expression of transcriptional target genes implicated in cell proliferation and signal transduction.