Improved methods for quantitation of acute phase proteins in biological samples.

生物样品中急性期蛋白定量的改进方法。

• 批准号: LP0347774
• 负责人: Prof Grant Booker
• 金额: $ 1.39万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-12-31 至 2006-12-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0347774
• 关键词: Improved; methods; quantitation; acute; phase

Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management of those at risk of heart attack, the single biggest contributor to healthcare costs in Australia. We further aim to adapt this technology to enable "point-of-care" assays that would help medical practitioners, especially in rural areas, to make informed diagnoses immediately.

使用单克隆抗体和荧光偏振，我们的目标是开发改进的定量分析方法，是上级目前的临床检测。最初的目标是C反应蛋白（CRP）和血清淀粉样前体蛋白（SAP），但该技术应该很容易适应其他血清蛋白。更好的CRP和SAP检测将大大促进改善心脏病发作风险人群的临床管理，心脏病发作是澳大利亚医疗保健成本的最大贡献者。我们的进一步目标是调整这项技术，使“即时”分析，这将有助于医疗从业者，特别是在农村地区，立即作出明智的诊断。