Study for the mechanism of HIV-1-specific CTL induction in the intestinal mucosa

在这项研究中，我们旨在阐明人类免疫缺陷病毒(HIV)特异性细胞毒性T淋巴细胞(CTL)在肠道中被诱导的机制。将表达HIV-1 Gag的鼠伤寒沙门氏菌AroA-或AroA-inAn突变体分别作为口服抗原接种小鼠，观察其是否能穿透Peyer氏斑。然而，GAG特异性CTL很难在全身和肠道粘膜间隔中诱导。需要进一步的研究，以便更好地了解Peyer‘s斑块在诱导粘膜CTL中的作用。

In this study, we aimed to elucidate the mechanism by which human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTLs) are induced in the intestine. HIV-1 Gag-expressing Salmonella typhimurium aroA- or aroA-invAmutants, which can or not, respectively, penetrate Peyer's patches, were used as oral antigens into mice. However, Gag-specific CTLs were hardly induced in both the systemic and the gut mucosal compartments. Further study should be needed for better understanding of the role of Peyer's patches in the induction of mucosal CTLs.