Study for the mechanism of HIV-1 latent infection in a humanized mouse model

本研究旨在通过分析人源化小鼠模型来阐明HIV-1潜伏感染的机制。人源化小鼠用CXCR 4-嗜性（X4）和/或CCR 5-嗜性（R5）HIV-1攻击。我们发现，R5 HIV-1优先靶向激活的记忆性CD 4 + T细胞，而与X4 HIV-1无关。相反，尽管X4 HIV-1基本上感染了活化的记忆性CD 4 + T细胞，但在R5 HIV-1存在下，细胞群中的感染效率显著降低。这些结果表明，各自的X4和R5 HIV-1储库由不同的CD 4 + T细胞亚群形成。

This study was aimed at elucidating the mechanism of latent infection of HIV-1 by analyzing a humanized mouse model. Humanized mice were challenged with CXCR4-tropic (X4) and/or CCR5-tropic (R5) HIV-1. We found that R5 HIV-1 preferentially targeted to activated memory CD4+ T cells irrespective of X4 HIV-1. In contrast, although X4 HIV-1 substantially infected to activated memory CD4+ T cells, the infection efficiency in the cell population was markedly reduced in the presence of R5 HIV-1. These results suggest that the respective X4 and R5 HIV-1 reservoirs are formed from different subsets of CD4+ T cells.