The relationship between protein levels and physiological parameters for cardiomyopathy

为了阐明心肌病的病理生理机制，我们对心肌病患者的钙调节蛋白mRNAs的含量和血流动力学参数进行了病理生理学分析。2010年，我们报道了扩张型心肌病患者多巴酚丁胺诱导的机械改变与钙处理蛋白mRNA水平的关系。2009年，肥厚性心肌病患者左心室线粒体出现功能障碍和形态紊乱。这些线粒体改变与心肌收缩和松弛储备受损有关。

To clarify pathophysiological mechanisms, we performed the pathophysiological analysis about the amounts of Ca-handling protein mRNAs levels and the hemodynamic parameters in patients with cardiomyopathy. In 2010, we reported that the relationship between dobutamine-induced mechanical alternans and mRNA levels of Ca-handling protein in patients with dilated cardiomyopathy. In 2009, Mitochondria showed functional impairment and morphological disorganization in the left ventricle of HCM patients. These mitochondrial changes were associated with impaired myocardial contractile and relaxation reserves.