Characterization of the earliest hematolymphoid progenitors that emerge during mouse development

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Blood cell types are involved in gas transport, hemostasis, bone resorption, and immune response. To understand the process of blood cell development during mouse ontogeny, we traced back the origin of the earliest multipotent blood cell progenitors we previously isolated to the mesodermal stage of development. The detailed analysis showed that primitive red blood cells, which are transiently produced during ontogeny, and multipotent blood cell progenitors share a common developmental pathway.