Elucidation of the mechanism for hematopoietic stem cell development

造血干细胞(HSC)是一种能够自我更新和分化为所有成熟血细胞系的细胞亚群。在这项研究中，我们鉴定了原始红细胞和多能造血细胞的共同前体，在HSC出现之前的小鼠早期发育中。我们比较了HSC前期造血细胞和HSC的基因表达谱。通过分析，我们确定了这些早期祖细胞和干细胞之间明显表达的基因，表明这些基因参与了血细胞系统的干性。

Hematopoietic stem cells (HSC) are a subset of cells that are capable of self-renewal and differentiation into all mature blood cell lineages. In this study, we identified the common precursors of primitive erythrocytes and multipotent hematopoietic cells in early mouse development before the emergence of HSC. We compared the gene expression profiles between pre-HSC stage hematopoietic cells and HSC. Though the analysis, we identified genes distinctly expressed between these early progenitors and stem cells, suggesting the involvement of these genes into the stemness of blood cell system.