Development of therapy for rheumatoid arthritis to correct the dysfunction of dendritic cells caused by human parvovirus B19

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In this study, we have the purpose to clarify the associations between the pathogenesis of autoimmunity and the dysregulation of cytokine signaling, because we experienced patients infected by human parvovirus B19 followed by onset of rheumatoid arthritis. Regulatory T cells (Tregs) are main cell subset to have suppressive immunological functions. However, the development or maintenance of Tregs has not been clarified to be associated with the dysregulation of cytokine signaling. Therefore, we examined the role of SOCS1, which is the negative regulation of the cytokine-JAK-STAT pathway, in Tregs. We clarified SOCS1 is necessary for Treg function to suppress cytokine signaling and Foxp3 maintenance.