Developmental roles of the subventricular zone-specific gene in the mammalian brain.

哺乳动物大脑中室下区特异性基因的发育作用。

• 批准号: 21791009
• 负责人: ARAMAKI Michihiko
• 金额: $ 2.41万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791009/
• 关键词: 発生・分化; 脳室下帯; 多極性細胞; microRNA; 大脳新皮質形成期

Mammalian cerebral cortex consists of six layers. Neurons in each layer communicate with each other and develop the complex networks. Highly sophisticated neuronal networks are considered to be origins of higher-order brain function in humans. Mammalian subventricular zone (SVZ) includes progenitor cells which generate massive amount of neurons during the brain development. In this study, we examined the expression level of SVZ-specific gene in human and mouse brain and proposed the microRNA-mediated regulatory mechanism of SVZ-specific gene expression.

哺乳动物的大脑皮层由六层组成。每一层的神经元之间相互通信，形成复杂的网络。高度复杂的神经元网络被认为是人类高级大脑功能的起源。哺乳动物脑室下区（SVZ）是脑发育过程中产生大量神经元的前体细胞。本研究检测了SVZ特异性基因在人和小鼠脑中的表达水平，并提出了microRNA介导的SVZ特异性基因表达调控机制。