Establishment of new treatment with Menkes disease by disulriram

门克斯病(MD)是一种由ATP7A基因突变引起的铜代谢进行性神经退行性变性的X连锁隐性铜缺乏症。它对结缔组织和神经退行性变不是有效的治疗方法。在本研究中，考察了双硫仑和铜联合给药对门克斯病小鼠黄斑病变的影响。提示铜和双硫胺联合应用是治疗Menkes病的有效方法。

Menkes disease (MD) is an X-linked recessive copper deficiency disorder with progressive neurological degeneration of copper metabolism caused by mutations in the ATP7A gene. It is not useful treatment for connective tissue and neurological degeneration. In this study, examined the effect of administration of combination with disulfiram and copper for macular mouse is a model for Menkes disease. It is suggested that combination with copper and disulfiram was useful methods for Menkes disease.