Development of a VEGFR3 imaging agent by PET for predictive diagnosis of lymph node metastasis.

本研究的目的是开发一种新的放射性标记的成像探针，以显示VEGFR 3受体，这是淋巴结转移的早期过程中的关键分子。因此，VEGFR 3的成像将适用于淋巴结转移的早期诊断。在这项研究中，11 C-标记的VEGFR 3及其前体的甲基化放射性标记成功地合成。用示踪剂进行的小动物PET成像显示在AH 109 A荷瘤大鼠的肿瘤组织中的放射性摄取。

The purpose of this study was to develop a new radiolabeled imaging probe to visualize a VEGFR3 receptor, which is a key molecule in the early process of lymph node metastasis. Thus, imaging of VEGFR3 would be applicable to early diagnosis of lymph node metastasis. In this study, 11C-labeled VEGFR3 and its precursor for radiolabeling by methylation was successfully synthesized. Small animal PET imaging with the tracer showed a radioactivity uptake in tumor tissue in an AH109A tumor bearing rat.