Development of a VEGFR3 imaging agent by PET for predictive diagnosis of lymph node metastasis.

这项研究的目的是开发一种新的放射性标记成像探针来显示VEGFR3受体，它是淋巴转移早期过程中的一个关键分子。因此，VEGFR3的显像可用于淋巴结转移的早期诊断。本研究成功地合成了11C标记的血管内皮生长因子受体3及其甲基化标记前体。使用示踪剂的小动物PET成像显示，AH109A荷瘤大鼠的肿瘤组织中有放射性摄取。

The purpose of this study was to develop a new radiolabeled imaging probe to visualize a VEGFR3 receptor, which is a key molecule in the early process of lymph node metastasis. Thus, imaging of VEGFR3 would be applicable to early diagnosis of lymph node metastasis. In this study, 11C-labeled VEGFR3 and its precursor for radiolabeling by methylation was successfully synthesized. Small animal PET imaging with the tracer showed a radioactivity uptake in tumor tissue in an AH109A tumor bearing rat.