Development of Computer-aided Classification System for early-onset Alzheimer' s Disease based on Three-dimensional Functional Magnetic Resonance Imaging

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In recent years, various sorts of computer-aided diagnosis(CAD) system for Alzheimer' s disease(AD) patients have been developed to evaluate the degree of the atrophy in the cerebral cortex using morphological features in MR images. In this study, we developed a CAD system for AD patients based on functional imaging features derived from the cerebral blood flow maps measured by arterial spin labeling(ASL) technique which is one of magnetic resonance imaging(MRI) techniques. Our preliminary results suggest that the proposed method based on functional imaging features obtained by the ASL technique would be feasible for detection of patients with AD and would be expected using for a screening examination and a follow-up examination under treatment of AD.