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In vivo imaging of viscoelasticity and hardness of biological soft tissue using ultrasound.

使用超声对生物软组织的粘弹性和硬度进行体内成像。

基本信息

批准号：
05680766
负责人：
YAMASHITA Yasuo
金额：
$ 1.28万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05680766/
关键词：
Local Strain Tensor Tissue Elasticity Tissue Hardness Local Tissue Deformation Relative Shear Modulus Ultrasonic Imaging In Vivo Imaging 超音波生体組織の硬さ局所歪テンソル変位分布変位歪生体組織の粘弾性

项目摘要

Changes in tissue elasticity are related to diffuse disease processes of living soft tissue. The goal of this study is to characterize tissue elasticity based on ultrasonic measurement of displacement and strain when the primary cardiac pulsation or the external mechanical force is applied to the soft tissue. A model is presented for the changes in tissue elasticity as a change of internal strain tensor, which results in variation in the Young's or shear modulus of elasticity. Mesurements are performed using real-time ultrasound and the sequences of RF echo signal returned from tissue are digitized to estimate local tissue displacement. In this paper the 2-dimensional distribution of internal displacement is estimated using the spatio-temporal derivative of RF echo envelope signals, from which components of internal strain tensor are computed. Experiments on tissue mimicking phantoms indicate that 2-dimensional fields of components of strain tensor can be estimated with the spatial resolution of 8mm*8mm. The distribution of the relative shear modulus based on strain images is reconstructed. In experiments with living soft tissue, such as liver in vivo, the relative shear modulus is large in less elastic regions. The elasticity of soft tissue can be characterized as the relative shear modulus computed from the local strain tenpor observed in the received RF echo signals.

组织弹性的变化与活体软组织的弥漫性疾病过程有关。本研究的目的是表征组织弹性的基础上超声测量的位移和应变时，主要心脏搏动或外部机械力施加到软组织。一个模型是作为内部应变张量的变化，这导致在杨氏或剪切弹性模量的变化，在组织弹性的变化。使用实时超声进行肠系膜切除，并且将从组织返回的RF回波信号序列数字化以估计局部组织位移。在本文中，内部位移的二维分布估计使用的RF回波包络信号的时空导数，从内部应变张量的分量计算。仿组织体模实验表明，该方法可以估计应变张量各分量的二维场，空间分辨率为8mm × 8mm。基于应变图像重建了相对剪切模量的分布。在活体软组织（如体内肝脏）的实验中，相对剪切模量在弹性较小的区域较大。软组织的弹性可以被表征为从在接收到的RF回波信号中观察到的局部应变tenpor计算的相对剪切模量。