Studies on the Function of Junctional Epithelium and the Mechanism of Epithelial Attachment

交界上皮功能及上皮附着机制的研究

• 批准号: 12671761
• 负责人: YAMASHITA Yasuo
• 金额: $ 2.18万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671761/
• 关键词: Gingiva; Junctional Epithlium; Epithelial Attachment; 歯肉接合上皮; 歯小皮; 歯肉溝

To investigate the function of the junctional epithelium and the mechanism of epithelial attachment, I chiefly observed a morphological feature of human teeth and gingiva by histological and immunohistochemical technique.A comparatively wide intercellular space was seen in junctional epithelium. It seemed that these intercellular space decreased mechanical pressure that the junctional epithelium receive while masticating. The epithelial cells that attach to the tooth surface have a lot of cell organelles and granular structures. Moreover, because a lot of infoldings of cell membrane and vesicles are observed near the cell membrane of the dentine side, it seems that these cells synthesize a certain kind of substance, and do absorption and the secretion vigorously. As for the hemidesmosome, basal lamina and the cell membrane of the epithelial cell that faced tooth, it was confirmed that the possibility to become a part of element that composed dental cuticle was high. Causing the expansion of the periodontal pocket by the disruption between junctional epithelial cells became clear in morphology

为探讨结合上皮的功能及上皮附着的机制，本研究采用组织学和免疫组化技术，观察了人牙和牙龈的形态学特征：结合上皮细胞间存在较宽的细胞间隙。这些细胞间隙似乎降低了咀嚼时连接上皮所受到的机械压力。附着在牙齿表面的上皮细胞具有许多细胞器和颗粒结构。此外，由于在牙本质侧的细胞膜附近观察到大量的细胞膜内折和囊泡，这些细胞似乎合成某种物质，并进行旺盛的吸收和分泌。对于牙面上皮细胞的半桥粒、基膜和细胞膜，证实其成为构成牙角质层的成分的可能性较高。结合上皮细胞间的断裂导致牙周袋扩张的形态学特征变得清晰