Elucidation of pathway and molecular mechanism of radiation-induced non-apoptotic cell death mode in human solid carcinoma cell

点击翻译按钮获取中文摘要

Live-cell imaging of mammary carcinoma cell line revealed prolonged cell cycle arrest as a predominant cell death mode induced by ionizing radiation. Regardless cell cycle phase that exposed to ionizing radiation, prolonged cell cycle arrest was induced in G1 phase. Particularly, direct cell cycle progression from G2 to G1 phase without mitosis was observed by G2-irradiation in presence of p53, suggesting that radiochemotherapy combined with taxane-treatment increases the treatment-sensitivity for p53-depleted carcinoma cells.