The mechanism of amplification in DNA-damage signaling for enhancement of radiosensitivity

DNA双链断裂触发信号转导通路的激活，包括诱导细胞死亡。最近的研究表明，DNA损伤信号的放大可能与有效诱导细胞死亡有关。在这项研究中，我们发现DNA损伤信号的放大在肿瘤细胞系中受到抑制，我们还证明了DNA损伤信号的放大具有细胞周期的时相依赖性。

DNA double-strand breaks trigger activation of signal transduction pathways including induction of cell death. Recently, it is suggested that the amplification of DNA damage signaling could be related to the effective cell death induction. In this study, we revealed that the amplification of DNA-damage signaling was suppressed in tumor cell lines.We also demonstrated cell cycle phase-dependency in the amplification of DNA-damage signaling.