Cryoablation for lung tumors : optimal freeze-thaw sequence and clinical application

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1) We drew the isothermal curves by measuring the temperature of a normal porcine lung in vivo based on the same freeze-thaw cycles as actual cryoablation for malignant lung tumors. As a result of the analysis with the isothermal curve and the freezing function, the frozen area of the iceball was larger in the second cycle than in the first cycle. It is supposed that bleeding in the first freeze-thaw cycle increases the thermal diffusivity around the cryoprobe and it is enabled to freeze a greater area in the second freezing. 2) The correlation between the isothermal curves and histologic findings was examined. These findings were also compared with the clinical findings on computed tomography(CT). The present study has demonstrated that the less than-20℃zone corresponds to the central solid zone on CT.