Clarification of a mechanism of metastasis in hepatocellular carcinoma based on hepatitis C virus infection by analysis of expression of Metastatic Tumor Antigen(MTA-1)

转移性肿瘤抗原（MTA-1）表达分析阐明基于丙型肝炎病毒感染的肝细胞癌转移机制

• 批准号: 21791277
• 负责人: ASAKAWA Masami
• 金额: $ 2.58万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791277/
• 关键词: 肝細胞癌; MTA-1; 肝内転移; HIF-1α; Rac; 無再発生存期間; CD31; α-SMA; MCSF; CD68マクロファージ; CD163マクロファージ; VEGF; EGF; 免疫染色; 血行性肝内転移; mRNA; MTA1; 多臓器転移; 肝転移; C型肝炎; 予後

VEGF which is induced by MAT-1 through HIF-1αwas highly expressed in the peritumor lesion where expression of MAT-1 was not found. So, MAT-1 has no connection with intrahepatic metastasis of hepatocellular carcinoma based on hepatitis C virus infection. Cytokines produced from the liver macrophage participate in intrahepatic metastasis of hepatocellular carcinoma because of the findings of highly invasion of liver macrophage and high expression of TGFβin the lesion where VGF is expressed

MAT-1通过HIF-1α诱导VEGF在瘤周病灶中高表达，而MAT-1未表达。因此，MAT-1与丙型肝炎病毒感染引起的肝细胞癌肝内转移无关。由于肝巨噬细胞高度侵袭且表达VGF的病灶中TGFβ高表达，肝巨噬细胞产生的细胞因子参与了肝细胞癌的肝内转移

项目成果

Lens culinaris agglutinin-reactive fraction of AFP is a useful prognostic biomarker for survival after repeat hepatic resection for HCC

• DOI: 10.1111/j.1440-1746.2010.06532.x
• 发表时间: 2011-04-01
• 期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
• 影响因子: 4.1
• 作者: Matsuda, Masanori;Asakawa, Masami;Fujii, Hideki
• 通讯作者: Fujii, Hideki

Double-Dose Gadoxetic Acid-Enhanced Magnetic Resonance Imaging in Patients With Chronic Liver Disease

• DOI: 10.1097/rli.0b013e3181f9c487
• 发表时间: 2011-02-01
• 期刊: INVESTIGATIVE RADIOLOGY
• 影响因子: 6.7
• 作者: Motosugi, Utaroh;Ichikawa, Tomoaki;Araki, Tsutomu
• 通讯作者: Araki, Tsutomu

肝細胞癌切除後10年以上無発症症例の検討からみえてきた

一项针对肝细胞癌切除后 10 多年未出现症状的患者的研究得出了什么结果

• 发表时间: 2011
• 作者: 松田政徳;他
• 通讯作者: 他

長期予後改善をめざした肝細胞癌治療-切除後再発の治療戦略とその成績

肝细胞癌治疗旨在改善长期预后——切除后复发的治疗策略和结果

• 发表时间: 2010
• 作者: 松田政徳;他
• 通讯作者: 他

Imag ing study of early hepatocellular car cinoma

早期肝细胞癌的影像学研究

• 发表时间: 2011
• 期刊: usefulness of gadoxetic acid-enhanced MR imaging
• 作者: Sano K;Ichikawa T;Motosugi U;Sou H;Muhi AM;Matsuda M;Nakano M;Sakamo to M;Nakazawa T;Asakawa M;Fujii H;Kitamura T;Enomoto N;Araki T
• 通讯作者: Araki T