Clarification of a mechanism of metastasis in hepatocellular carcinoma based on hepatitis C virus infection by analysis of expression of Metastatic Tumor Antigen(MTA-1)

MAT-1通过HIF-1α诱导的血管内皮细胞生长因子在瘤周高表达，而MAT-1不表达。因此，MAT-1与丙型肝炎病毒感染所致肝细胞癌的肝内转移无关。肝巨噬细胞的高侵袭性和转化生长因子β的高表达参与了肝细胞癌的肝内转移

VEGF which is induced by MAT-1 through HIF-1αwas highly expressed in the peritumor lesion where expression of MAT-1 was not found. So, MAT-1 has no connection with intrahepatic metastasis of hepatocellular carcinoma based on hepatitis C virus infection. Cytokines produced from the liver macrophage participate in intrahepatic metastasis of hepatocellular carcinoma because of the findings of highly invasion of liver macrophage and high expression of TGFβin the lesion where VGF is expressed