The control of neural-glial spinal cells microenvironment after traumatic injury through transfection of neurotrophic factor

安全、有效地给药神经营养素具有重要意义。我们的研究结果表明，有针对性的逆行腺病毒BDNF基因在体内传递可能会提高神经元和少突胶质细胞的生存持续机械压迫脊髓损伤。细胞凋亡的抑制可能是这些阳性结果的机制之一。该方法是一种潜在的合适的方法，用于传递治疗基因，重要的是促进创伤性脊髓损伤后神经元和少突胶质细胞的存活。

It is very important to deliver the neurotrophins with safety and effectively. Our results suggest that targeted retrograde AdV-BDNF-gene in vivo delivery may enhance neuronal and oligodendroglial survival sustained mechanical compression spinal cord injury. The suppression of apoptosis may one of the mechanism of these positive results. The method is a potentially suitable approach for the delivery of therapeutic genes important to promote the survival of neurons and oligodendroglia after traumatic spinal cord injury.