The control of neural-glial spinal cells microenvironment after traumatic injury through transfection of neurotrophic factor

如何安全、有效地给药是非常重要的。我们的结果提示，体内靶向逆行携带AdV-BDNF-基因可以提高持续机械压迫脊髓损伤后神经元和少突胶质细胞的存活。抑制细胞凋亡可能是这些积极结果的机制之一。该方法是一种潜在的适合于治疗基因的传递方法，该基因对于促进创伤性脊髓损伤后神经元和少突胶质细胞的存活至关重要。

It is very important to deliver the neurotrophins with safety and effectively. Our results suggest that targeted retrograde AdV-BDNF-gene in vivo delivery may enhance neuronal and oligodendroglial survival sustained mechanical compression spinal cord injury. The suppression of apoptosis may one of the mechanism of these positive results. The method is a potentially suitable approach for the delivery of therapeutic genes important to promote the survival of neurons and oligodendroglia after traumatic spinal cord injury.