Contributions of Cytogenetics and Molecular Genetics to the Diagnosis and Treatment of Malignant Soft Tissue Tumors

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We established a new permanent human malignant fibrous histiocytoma cell line. Molecular cytogenetic analyses revealed a homozygous deletion of p16 and a high-level amplification of 9q31-34 in this cell line. CSFJ rearrangement was identified in about 60% of pigmented villonodular synovitis/giant cell tumor of tendon sheath cases. Also, the presence of CSFIR amplification was not identified in any cases examined. High-level amplification of 12q13-15 was found in well-differentiated liposarcomas and dedifferentiated liposarcomas but not in benign adipocytic tumors.