Central nervous system effect of local anesthetics : Influences on electroencephalogram and electroencephalographic changes induced by co-administered opioids
Central nervous system effect of local anesthetics : Influences on electroencephalogram and electroencephalographic changes induced by co-administered opioids
批准号:
21791468
负责人:
TANAKA Katsuaki
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
在全身麻醉下,在大鼠伏隔核内置入微透析引导管。在对侧伏隔核放置一个脑电图电极。然后,在清醒状态下进行连续的局部脑电图测量和局麻药定量。在人体研究中,研究了通过硬膜外导管给药的局部麻醉剂和静脉注射阿片类镇痛药对双谱指数(BIS)的影响。持续硬膜外注射局麻药1小时后,BIS脑电图变化稳定。提示局麻药和阿片类镇痛药的作用部位浓度达到稳定状态。
英文摘要
Under general anesthesia, a guide cannula for microdialysis was placed into nucleus accumbens of a rat. And an electroencephalogram electrode was placed into opposite nucleus accumbens. Thereafter, serial measurement of topical electroencephalogram and quantification of local anesthetics were enabled in awake state. In human study, influences on bispectral index(BIS) induced by local anesthetics administered via epidural catheters and by co-administered opioid analgesics intravenously were investigated. Following one hour after continuous epidural infusion of local anesthetics, electroencephalographic changes of BIS were stabilized. This finding suggests that effect site concentration of local anesthetics and of opioid analgesics reached steady state.
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共 29 条
Extraction and reorganization of topic transition patterns in recorded document
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批准号:20700129
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负责人:TANAKA Katsuaki
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Study on Japanese corporate ratings by Rating agencies with Artificial Neural Network and Self-organizing Maps
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批准号:19530374
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Differential diagnosis of hepatic tumors by pattern-based classification according to Bayes theorem
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The research on Optimal media selection models Using Data Envelopment Analysis and neural networks
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Uprequlation of anti-HCV activity
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负责人:TANAKA Katsuaki
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