Pericyte coverage of differentiated microvessels in clear cell renal cell carcinoma correlates with poorer prognosis

透明细胞肾细胞癌中分化微血管的周细胞覆盖与较差的预后相关

• 批准号: 21791526
• 负责人: MATSUDA Daisuke
• 金额: $ 2.75万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791526/
• 关键词: 淡明腎細胞癌; 血管周皮細胞; 血管内皮細胞; 腎細胞癌

Purpose : The clinical significance of vascular maturation, which is marked by the presence of the pericytes, is still unclear. In the present study, we evaluated the correlation between vascular maturation and patients' prognosis in CCRCC.Experimental Design : We analyzed formalin-fixed, paraffin-embedded tissue sections from 162 primary and 20 metastatic CCRCC patients. The sections were double-stained with pericyte marker anti-SMA antibody as an indicator of vascular maturation and the differentiated blood vessel marker anti-CD34 antibody. The Nuance Multispectral Imaging System was used to quantify those two cell types. We investigated the relationship between pericyte coverage(PC) and the clinicopathological parameters such as tumor grades, metastasis status, and patient survival.Results : Lower PC were significantly correlated with higher tumor grades and poorer patient's prognosis. Lower PC was also significantly correlated with metastasis. More matured differentiated blood vessels seem to indicate better prognosis. The present study suggested that vascular maturation in CCRCC was important.

目的：以周细胞的存在为标志的血管成熟的临床意义仍不清楚。在本研究中，我们评估了 CCRCC 中血管成熟度与患者预后之间的相关性。实验设计：我们分析了 162 名原发性 CCRCC 患者和 20 名转移性 CCRCC 患者的福尔马林固定、石蜡包埋的组织切片。将切片用作为血管成熟指标的周细胞标记物抗 SMA 抗体和分化血管标记物抗 CD34 抗体进行双重染色。 Nuance 多光谱成像系统用于量化这两种细胞类型。我们研究了周细胞覆盖率（PC）与肿瘤分级、转移状态和患者生存等临床病理参数之间的关系。结果：较低的PC与较高的肿瘤分级和较差的患者预后显着相关。较低的PC也与转移显着相关。分化血管越成熟似乎预示着更好的预后。本研究表明 CCRCC 中血管成熟很重要。

项目成果

Identification of copy number alteration in clear cell and papillary RCC

透明细胞和乳头状肾细胞癌中拷贝数改变的鉴定

• 发表时间: 2009
• 作者: 松田大介

Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma.

• DOI: 10.1186/1471-2407-10-196
• 发表时间: 2010-05-12
• 期刊: BMC cancer
• 影响因子: 3.8
• 作者: Tan MH;Wong CF;Tan HL;Yang XJ;Ditlev J;Matsuda D;Khoo SK;Sugimura J;Fujioka T;Furge KA;Kort E;Giraud S;Ferlicot S;Vielh P;Amsellem-Ouazana D;Debré B;Flam T;Thiounn N;Zerbib M;Benoît G;Droupy S;Molinié V;Vieillefond A;Tan PH;Richard S;Teh BT
• 通讯作者: Teh BT

Cost comparison of curative therapies for localized prostate cancer in Japan : a single-institution experience

日本局限性前列腺癌治疗费用比较：单一机构的经验

• 发表时间: 2009
• 期刊: Jpn J Radiol
• 影响因子: 2.1
• 作者: Satoh T;Ishiyama H;Matsumoto K;Tabata K;Kitano M;Iwamura M;Kimura M;Minamida S;Yamashita H;Matsuda D;Kotani S;Niibe Y;Uemae M;Hayakawa K;Baba S
• 通讯作者: Baba S

Multicentric hyaline-vascular Castleman's disease treated by laparoscopic resection

腹腔镜切除治疗多中心透明血管卡斯尔曼病

• 发表时间: 2009
• 期刊: Int J Urol
• 影响因子: 2.6
• 作者: Matsuda;D.;Iwamura;M.;Baba;S
• 通讯作者: S

INFLUENCE OF BODY MASS INDEX IN LAPAROSCOPIC RADICAL NEPHRECTOMY : THE CORRELATION WITH PERIRENAL OR SUBCUTANEOUS FAT THICKNESS

体重指数对腹腔镜根治性肾切除术的影响：与肾周或皮下脂肪厚度的相关性

• 发表时间: 2010
• 作者: T Fujita;M Iwamura;H Tsumura;D Matsuda;ほか3名
• 通讯作者: ほか3名