Paracrine regulation of cell proliferation between ER (+) and ER (-) cell line cells
Paracrine regulation of cell proliferation between ER (+) and ER (-) cell line cells
批准号:
21791547
负责人:
ISHIDA Maho
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
利用稳定转染雌激素受体α(ERα)的MDA-MB-231细胞,建立ER(+)和ER(-)MDA-MB-231细胞共培养体系。ER(+)和ER(-)细胞的比例为1:1、4:1和10:1。在所有情况下,10 nM 17β-雌二醇处理48 h可抑制ER(+)细胞的细胞增殖,但不影响通过邻近ER(+)细胞以旁分泌方式促进ER(-)细胞的细胞增殖。
英文摘要
Using MDA-MB-231 cells stably transfected with estrogen receptor α (ERα), co-culture system with ER (+) and ER (-) MDA-MB-231 cells was established. The ratios of ER (+) and ER (-) cells were 1:1, 4:1, and 10:1. In all cases, treatment with 10nM 17β-estradiol for 48 h inhibited the cell proliferation of ER (+) cells but had no effect to promote the cell proliferation of ER (-) cells in a paracrine manner through the neighboring ER (+) cells.
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Inhibition of estrogen receptor transcriptional activity by dopamine receptor activation in pituitary lactotrophs
通过激活垂体催乳素中的多巴胺受体抑制雌激素受体转录活性
DOI:
--
发表时间:
2011
期刊:
The Journal of Physiological Sciences
影响因子:
--
作者:
[Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y., Maho Ishida]
通讯作者:
Maho Ishida
The cAMP response element-binding protein in the bed nucleus of the s tria terminalis modulates the formalin-induced pain behavior in the female rat
终丝床核中的 cAMP 反应元件结合蛋白调节雌性大鼠福尔马林诱导的疼痛行为
DOI:
--
发表时间:
2009
期刊:
European Journal of Neuroscience Vol.30
影响因子:
--
作者:
[Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y., Maho Ishida, Maho Ishida, Hiroko Hagiwara]
通讯作者:
Hiroko Hagiwara
Absence of ligand-independent transcriptional activation of the estrogen receptor via the estrogen response element in pituitary lactotrophs in primary culture
原代培养的垂体催乳素中不存在通过雌激素反应元件对雌激素受体进行配体依赖性转录激活
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Maho Ishida]
通讯作者:
Maho Ishida
Absence of ligand-independent transcriptional activation of the estrogen receptor via the estrogen response element in pituitary lactotrophs in p rimary culture
原代培养物中垂体催乳素细胞中雌激素受体通过雌激素反应元件不存在配体依赖性转录激活
DOI:
--
发表时间:
2010
期刊:
Journal of Steroid Biochemistry & Molecular Biology. Vol.118
影响因子:
--
作者:
[Takamura M, Koga K, Osuga Y, Takemura Y, Hamasaki K, Hirota Y, Yoshino O, Taketani Y., Maho Ishida, Maho Ishida]
通讯作者:
Maho Ishida
下垂体プロラクチン細胞におけるドーパミンD2受容体活性化によるエストロジェン受容体転写活性の抑制
垂体催乳素细胞中多巴胺 D2 受体激活抑制雌激素受体转录活性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Nakashima A, Ito M, Shima T, Bac ND, Hidaka T, Saito S.Am.J, 石田真帆]
通讯作者:
石田真帆
共 6 条
Molecular mechanism of anti-mitogenic effects of estrogen on breast cancer cells
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批准号:26462518
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2014
-
负责人:ISHIDA Maho
-
依托单位:
Effects of estrogen receptor expression in paracrine regulation of cell proliferation of mammary gland epithelial cell line
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批准号:23791823
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2011
-
负责人:ISHIDA Maho
-
依托单位:
海外基金