Identification of endometrial cancer stem cells and endometrial stem cells for establishment of new molecular-targeting therapy

鉴定子宫内膜癌干细胞和子宫内膜干细胞以建立新的分子靶向治疗

• 批准号: 21791564
• 负责人: TSUNEMATSU Ryosuke
• 金额: $ 2.75万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791564/
• 关键词: 子宮体癌幹細胞; 子宮内膜幹細胞; SP細胞; Ras; ER経路; 細胞老化; Ras/ER経路

FACS analysis of human endometrial cells recovered from menstrual blood revealed that they included about 2% of SP(side population) cells. Colony formation assay using SP cells and non-SP cells showed that SP cells formed colonies more efficiently than non-SP cell. These results indicated that SP cells recovered from human menstrual blood have self-renewing ability. Immunocytochemical staining of hEM SP cells for IL-1R and CXCR4 revealed that a few SP cells expressed both proteins.

从月经血中回收的人子宫内膜细胞的FACS分析表明，这些细胞中约有2%的SP(侧群)细胞。用SP细胞和非SP细胞进行的集落形成实验表明，SP细胞的集落形成效率高于非SP细胞。这些结果表明，从月经血中回收的SP细胞具有自我更新能力。免疫细胞化学染色显示少数SP细胞同时表达IL-1R和CXCR4。

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