The aim to elucidate the mechanism of peripheral vestibular function recovery process

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We reported the process of vestibular function in the unilateral vestibular re-input model using tetrodotoxin(TTX) with osmotic pump in the guinea pig.The aim of this study is to clarify the process of the neural activity in our model in the guinea pig brainstem. We observed the pCREB labeling neurons in the brainstem at several post-operative intervals in UL and TTX-treated animals. In both groups, the pCREB labeling neurons were detectable in both sides of the vestibular nucleus at early period. In both groups, the pCREB labeling neurons were detectable in both sides of the vestibular nucleus at early period.