The study for the expression and the role of thermo-sensitive TRP channels.

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The relationship between the nose and thermo-sensitive TRP channels using fluorescent immunohistochemistry and confocal laser scan microscope was examined. Specific distribution of TRPV1 and TRPM8 was found in the human inferior turbinate. Moreover, co-localization of the inflammatory mediators SP, CGRP, a nerve marker PGP9.5 with TRPV1 and M8 were examined.These findings suggest the possibility of a new mechanism to regulate the nasal conditions without autonomic nerve reflex.