The study for the expression and the role of thermo-sensitive TRP channels.

研究热敏TRP通道的表达和作用。

• 批准号: 21791658
• 负责人: SHIBATA Minori
• 金额: $ 2.58万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791658/
• 关键词: 鼻科学; 温度センサー; TRPチャネル; ヒト; 鼻

The relationship between the nose and thermo-sensitive TRP channels using fluorescent immunohistochemistry and confocal laser scan microscope was examined. Specific distribution of TRPV1 and TRPM8 was found in the human inferior turbinate. Moreover, co-localization of the inflammatory mediators SP, CGRP, a nerve marker PGP9.5 with TRPV1 and M8 were examined.These findings suggest the possibility of a new mechanism to regulate the nasal conditions without autonomic nerve reflex.

用荧光免疫组织化学和激光共聚焦扫描显微镜观察鼻部与热敏感色氨酸通道的关系。在人下鼻甲中发现了TRPV1和TRPM8的特异性分布。此外，对炎症介质P物质、降钙素基因相关肽、神经标记物PGP9.5与TRPV1、M8的共定位进行了研究。这些发现表明，在没有自主神经反射的情况下，可能有一种新的机制来调节鼻部状况。

项目成果

The relationship between nose and temperature-implication of thermo-sensitive transient receptor potential

鼻子与温度的关系——热敏瞬时感受器电位的影响

• 发表时间: 2009
• 作者: Shibata M;Wakasugi T;Suzuki H
• 通讯作者: Suzuki H

ヒト下鼻甲介における温度感受性TRPチャネルの発現の検討

人下鼻甲温度敏感 TRP 通道表达的检测

• 发表时间: 2009
• 作者: 峰晴昭仁;金沢敦子;萩森伸一;森京子;野中隆三郎;竹中洋;柴田美雅
• 通讯作者: 柴田美雅