Development of rejection-free corneal transplantation using cultured corneal endothelial cell

利用培养角膜内皮细胞开发无排斥角膜移植

• 批准号: 21791698
• 负责人: HAYASHI Takahiko
• 金额: $ 2.83万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791698/
• 关键词: 眼免疫学

To resolve severe worldwide shortage of donors, we established a mouse model in which cultured allocorneal endothelium was transplanted onto a recipient mouse cornea. During the follow-up period, the transplanted cultured allo-corneal endothelium did not show any sign of allograft rejection. Realization of the clinical application of cultured allo-corneal endothelium transplantation may be a shortcut to ideal rejection-free corneal transplantation.

为了解决世界范围内供体严重短缺的问题，我们建立了一种小鼠模型，其中培养的同种异体角膜内皮细胞移植到受体小鼠角膜上。在随访期间，移植的培养同种异体角膜内皮细胞未显示任何同种异体排斥反应的迹象。培养的同种异体角膜内皮移植的临床应用的实现可能是实现理想的无排斥反应角膜移植的捷径。

项目成果

Immunologic Mechanisms of Corneal Allografts Reconstituted from Cultured Allogeneic Endothelial Cells in an Immune-Privileged Site

• DOI: 10.1167/iovs.08-2530
• 发表时间: 2009-07-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Hayashi, Takahiko;Yamagami, Satoru;Mizuki, Nobuhisa
• 通讯作者: Mizuki, Nobuhisa