EDUCATIONAL PLAN FOR OCULAR IMMUNOLOGY AND UVETITS STUDY

眼免疫学和 UVETS 研究教育计划

• 批准号: 3086716
• 负责人: GARY A PESICKA
• 金额: $ 7.13万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3086716
• 关键词: T lymphocyte; antiinflammatory agents; autoimmune disorder; cyclophosphamide; cyclosporines; dexamethasone; disease /disorder model; eye neoplasms; fibrosarcoma; gene expression; genetic transcription; histopathology; immunogenetics; immunosuppressive; mast cell neoplasm; model design /development; monoclonal antibody; neoplasm /cancer genetics; neoplasm /cancer immunology; neoplasm /cancer transplantation; uveitis

Ocular inflammatory diseases are a significant cause for loss of vision. Recent evidence indicates that many uveitis entities are immunologically mediated. Thus, any fundamental study of uveitis demands competence in ocular immunology. To achieve this competence a sufficient level of knowledge and skill in basic immunologic research technology is sought through a Physician Scientist Award. Under the sponsorship of Dr. Jerry Y. Niederkorn and involvement in particular with (1) analysis of spontaneous immune rejection of syngeneic intraocular tumors and (2) development of a mouse model of lens-induced endophthalmitis, as well as other ongoing studies in general, an understanding of ocular immunology will be developed. Also, through consultation with R. B. Nussenblatt, M.D., clinical expertise in the evaluation and treatment of patients with uveitis along with exposure to current uveitis research will be obtained. A complete didactic program will be fashioned as well. Ultimately, as an independent investigator, the exploration of basic, immunologic questions in uveitis will be initiated. As further insight is gained in understanding uveitis improved means of diagnosing and treating uveitis patients in a developed clinical practice would ensue. Previous clinical training in vitreoretinal disease would provide the surgical ability that is occasionally necessary in caring for patients with uveitis.

眼部炎症性疾病是导致视力丧失的重要原因。 最近的证据表明，许多葡萄膜炎实体是免疫学 调解。 因此，任何葡萄膜炎的基础研究都需要具备以下能力： 眼免疫学 为了达到这一能力， 寻求基本免疫学研究技术知识和技能 通过一个医生科学家奖。 在Jerry Y.博士的赞助下。 Niederkorn和参与，特别是与（1）分析自发的 同基因眼内肿瘤免疫排斥反应和（2） 晶状体诱导的眼内炎的小鼠模型，以及其他正在进行的 一般来说，对眼部免疫学的理解将是 开发 同时，通过与R. B。Nussenblatt，医学博士， 葡萄膜炎患者的评估和治疗的临床专业知识 沿着暴露于当前葡萄膜炎的研究将获得。 一 还将制定完整的教学计划。 最终，作为一个独立的调查员， 葡萄膜炎的免疫学问题将被启动。 进一步的见解是， 对葡萄膜炎的认识提高了诊断和治疗手段 在发达的临床实践中，葡萄膜炎患者将随之而来。 先前 玻璃体视网膜疾病的临床培训将提供手术 在照顾葡萄膜炎患者时偶尔需要的能力。