Systematic pressure measurement and histological analysis of rat Lymphedema model and LVA model

大鼠淋巴水肿模型和LVA模型的系统压力测量和组织学分析

• 批准号: 21791749
• 负责人: NOMURA Hiroshi
• 金额: $ 1万
• 依托单位: Dokkyo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791749/
• 关键词: 外科; 臨床; 病理学; 動物; 応用動物・マイクロサージェリー学; 応用動物

We made Lewis rat Lymphedema model, by ring-shaped excision of subcutaneous tissue of unilateral hind limb. And we measured circumference, volume, and systematic pressure of rat hind limb before and after producing Lymphedema model. The average measurements before producing Lymphedema model was as follows : circumference 7.3±1.2cm, volume 8.4±5.7ml, and systematic pressure 10.5±2.9mmHg. The average measurements two weeks after producing Lymphedema model was as follows : circumference 7.2±2.1cm, volume 10.4±3.8ml, and systematic pressure 12.5±3.1mmHg.Volume and systematic pressure increased after producing Lymphedema model.

采用环状切除一侧后肢皮下组织的方法制作Lewis大鼠淋巴水肿模型。并在制备淋巴水肿模型前后测量大鼠后肢的周长、体积和体压。模型制作前平均测量周径7.3±1.2 cm，体积8.4±5.7ml，体压10.5±2.9 mm Hg。建立淋巴水肿模型后2周，平均测量周径7.2±2.1 cm，体积10.4±3.8ml，体压12.5±3.1 mm Hg。

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