Novel function of the signaling molecule, PRIP.
Novel function of the signaling molecule, PRIP.
批准号:
21791807
负责人:
TAKEUCHI Hiroshi
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
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英文摘要
In this study, we examined the role of PRIP in regulated exocytosis, the universal cellular process through which various hormones, neurotransmitters and cytokines are secreted. We discovered that PRIP negatively regulates exocytosis by competing for membrane phospholipid, PtdIns(4,5)P_2 with a Ca^<2+>-dependent priming factor, CAPS. We also found that PRIP can also inhibit exocytosis independent of its PtdIns(4,5)P_2-binding ability.
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Assay of dense-core vesicle exocytosis using permeabilized PC12 cells.
使用透化 PC12 细胞测定致密核心囊泡胞吐作用。
DOI:
--
发表时间:
2010
期刊:
Adv.Enzyme Regul. 50
影响因子:
--
作者:
[Gao, J., Takeuchi, H., Umebayashi, H., Zhang, Z., Matsuda, M., Hirata, M.]
通讯作者:
M.
PRIP, a new Ins (1,4,5)P_3 binding protein, its extension toneuroscience and beyond.
PRIP,一种新的 Ins (1,4,5)P_3 结合蛋白,其延伸神经科学及其他领域。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Hirata, M., et al.]
通讯作者:
et al.
Pleckstrin homology domain of PRIP inhibits exocytosis in PC12 cells by binding to phosphatidylinositol 4,5-bisphosphate.
PRIP 的 Pleckstrin 同源结构域通过与磷脂酰肌醇 4,5-二磷酸结合来抑制 PC12 细胞中的胞吐作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Gao, J., et al.]
通讯作者:
et al.
Regulatory role of PRIP in exocytosis through the interaction with protein phosphatase.
PRIP 通过与蛋白磷酸酶相互作用在胞吐作用中发挥调节作用。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Gao, J., Takeuchi, H., Zhang, Z., Hirata, M.]
通讯作者:
M.
Inhibitory role of PRIP in dense core vesicle exocytosis.
PRIP 对致密核心囊泡胞吐作用的抑制作用。
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Takeuchi, H., et al.]
通讯作者:
et al.
共 31 条
Study on Development of Support System for Healthcare Against Metabolic-Syndrome
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批准号:20300222
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.23万
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财政年份:2008
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负责人:TAKEUCHI Hiroshi
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依托单位:
Roles of a novel signaling molecule in salivary secretion
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批准号:19791368
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项目类别:Grant-in-Aid for Young Scientists (B)
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财政年份:2007
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负责人:TAKEUCHI Hiroshi
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Improvement of a geometry optimization method for molecular clusters and its application
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批准号:19550001
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.0万
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财政年份:2007
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负责人:TAKEUCHI Hiroshi
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依托单位:
Personal Dynamic Healthcare System Utilizing Mobile Phone and Web technologies
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批准号:16500457
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:TAKEUCHI Hiroshi
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依托单位:
studies on the relationship of the structure of manifolds and p-harmonic functions
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批准号:16540208
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.2万
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财政年份:2004
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负责人:TAKEUCHI Hiroshi
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The properties of P-harmonic maps and the application to Geometry
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批准号:11640221
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.11万
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财政年份:1999
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负责人:TAKEUCHI Hiroshi
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依托单位:
Pollution of molluscicide and concentration in organs.
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批准号:07045047
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$0.96万
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财政年份:1995
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负责人:TAKEUCHI Hiroshi
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依托单位:
Signal transduction systems of achatin-I,a neuropeptide having a D-phenylalanine residue.
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批准号:06680758
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.96万
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财政年份:1994
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负责人:TAKEUCHI Hiroshi
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依托单位:
Study for the effects of neuroactive peptides newly isolated
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批准号:04044075
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$3.07万
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财政年份:1992
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负责人:TAKEUCHI Hiroshi
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依托单位:
Neurophysiological and neuropharmacological investigations of achatin-I, a neuroactive peptide having a D-Phe residue.
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批准号:02670049
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1990
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负责人:TAKEUCHI Hiroshi
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依托单位:
Study for the isolation of neuroactive peptides from the ganglia of Achatina fulica Ferussac.
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批准号:02044061
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$2.88万
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财政年份:1990
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负责人:TAKEUCHI Hiroshi
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依托单位:
Separation of Proteins by a Liquid Membrane with Reverse Micelles
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批准号:01550730
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1989
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负责人:TAKEUCHI Hiroshi
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依托单位:
One-step Amination by Parent Nitrenium Ion and Alkylnitrenium Ion
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批准号:63490013
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资助金额:$4.22万
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财政年份:1988
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负责人:TAKEUCHI Hiroshi
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依托单位:
Active Transport of Heavy Metal Ions through Polymeric Blended Membranes
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批准号:62550694
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1987
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负责人:TAKEUCHI Hiroshi
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依托单位:
Lymphocyte Subsets and Tissue Destruction in Periodontitis
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批准号:62570820
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.47万
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财政年份:1987
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负责人:TAKEUCHI Hiroshi
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依托单位:
Mechanism of Degradation of Liquid Membranes and Washout Characteristics of the Membrane Liquids
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批准号:60550663
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.45万
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财政年份:1985
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负责人:TAKEUCHI Hiroshi
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依托单位:
Reactivities of Nitrenium Ion Intermediates and the Application to Organic Syntheses
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批准号:60490007
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.14万
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财政年份:1985
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负责人:TAKEUCHI Hiroshi
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依托单位:
海外基金