Elucidation of hydrogen sulfide-producing mechanism by oral bacteria and searching for novel prophylactic drugs that prevent oral malodor

点击翻译按钮获取中文摘要

In this study, I focused on oral bacteria that highly produce hydrogen sulfide, a causative agent of oral malodor, and determined the structure of hydrogen sulfide-producing enzymes and their complex with a substrate analogue. We also succeeded to trap reaction intermediates. On the basis of structural information and/or enzymological data, conformational changes of enzyme during reaction and roles of amino acid residues at the active site were revealed. These results are quite important to descript their enzymatic reaction mechanisms and are expected to lead the search for novel prophylactic drugs that prevent oral malodor.