Research for developing drug to inhibit malignant melanoma bone metastasis by targeting Wnt5a signaling

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Many osteoclasts are formed and resorb bone, in malignant melanoma metastasizing. Then we investigated expression profiling of microRNAs during osteoclast differentiation. During osteoclast formation stimulated by RANKL, which induces osteoclast differentiation, 52 mature microRNAs varied more than twofold between untreated cells and RANKL treated cells. We observed the time-dependent down-regulation of the microRNAs miR-223 and miR-342-3p during osteoclastogenesis. By contrast, the levels of miR-210 and miR-378 increased. It suggests that many microRNAs play roles in osteoclast differentiation.