Continual Gram-negative bacterial challenge accelerates stroke onset SHRSP rats

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This study examined the effects of continual Gram-negative bacterial challenge on stroke onset. Stroke onset occurred significantly earlier in Stroke-prone spontaneously hypertensive rats(SHRSP) injected with a bacterial cell suspension of Gram-negative rods or lipopolysaccharides, as compared to uninjected controls. Paralysis of the hindlimb, piloerection, hypokinesis, and hyperkinesis were observed in lipopolysaccharide-injected SHRSP but not in uninjected controls during stroke onset. The serum levels of NOx, TBARS, and 8-OHdG increased in lipopolysaccharide-injected SHRSP. These results suggest that continual Gram-negative bacterial challenge induces accelerated stroke onset in SHRSP, probably caused by oxidative stress responses derived from lipopolysaccharides.