Nuerophysical analysis about nausea and vomiting-Function of hyperpolarization activated cation channel-

超极化激活的阳离子通道（Ih通道）在中枢神经系统中起着起搏器的作用，但Ih通道在后脑区（AP）中的功能作用尚未完全了解。因此，本研究的目的是阐明Ih通道的电生理作用，西维美林在AP中的激活和恶心呕吐的机制。本研究提示AP神经元可能参与西维美林引起的恶心和呕吐。

Hyperpolarization-activated cation channel (Ih channel) acts as the pacemaker in the central nervous system, and the functional role of Ih channel in the area postrema (AP) has not been fully understood. So the aim of this study was to elucidate the electrophysiological role of Ih channel, the activation for cevimeline in AP and the mechanism of nausea and vomiting. This study suggests that AP neurons may contribute to the cevimeline-induced nausea and vomiting.