Predict conversion to Alzheimer's disease from amnestic mild cognitive impairment

预测从遗忘性轻度认知障碍转变为阿尔茨海默病

• 批准号: 23700840
• 负责人: KODAMA Naoki
• 金额: $ 1.41万
• 依托单位: Takasaki University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23700840/
• 关键词: 認知症; アルツハイマー型認知症; 軽度認知障害; 進行予測; 早期診断; 脳萎縮; コンピュータ支援診断; コンピュータ支援診断システム

We analyzed the clinical test data of the Alzheimer's dementia (AD) patients and mild cognitive impairment patients whom we were able to follow-up more than two years.Voxel-based Specific Regional analysis system for Alzheimer's Disease (VSRAD) scores of CDR0.5 were 2.29+/-1.39. However, VSRAD scores were higher of 2.71+/-1.53 two years later. This result was the same as CDR1 and CDR2. The parahippocampal gyrus atrophy was every year. In addition, the score of the calculation and the recall of MMSE decreased every year. Furthermore, VSRAD scores were significantly higher at first medical examination in the patients with conversion to AD than in the patients without the conversion, the scores can be used as a predictive marker.

对随访两年以上的阿尔茨海默病(AD)患者和轻度认知障碍患者的临床测试数据进行了分析，基于体素的阿尔茨海默病特异性区域分析系统(VSRAD)的CDR0.5得分为2.29+/-1.39。两年后VSRAD评分为2.71+/-1.53。这一结果与CDR1和CDR2相同。海马区旁回萎缩呈逐年增加趋势。此外，MMSE的计算和回忆成绩呈逐年下降趋势。此外，转换为AD的患者首次体检时VSRAD评分显著高于未转换的患者，该评分可作为预测指标。

项目成果

Computerized method for classification between dementia with Lewy bodies and Alzheimer's disease by use of texture analysis on brain MRI

利用脑 MRI 纹理分析对路易体痴呆和阿尔茨海默病进行计算机分类的方法

• 发表时间: 2009
• 作者: Naoki Kodama;Yasuhiro Kawase
• 通讯作者: Yasuhiro Kawase

VSRADによる認知症患者の脳萎縮変化

VSRAD 导致痴呆患者脑萎缩的变化

• 发表时间: 2013
• 期刊: 日本放射線技師教育学会論文誌
• 作者: 児玉直樹;川瀬康裕
• 通讯作者: 川瀬康裕

認知症の脳血流量と神経心理検査データの時系列データ解析

痴呆患者脑血流及神经心理学测试数据的时间序列数据分析

• 发表时间: 2014
• 作者: 高橋真悟;上野宏樹;児玉直樹;小杉尚子;竹内裕之
• 通讯作者: 竹内裕之

Patterns of atrophy in dementia with Lewy bodies; a voxel-based morphometry (VBM) study

路易体痴呆症的萎缩模式；

• 发表时间: 2014
• 作者: Naoki Kodama;Yauhiro Kawase
• 通讯作者: Yauhiro Kawase

Can we predict conversion to Alzheimer's disease from amnestic MCI (Mild Cognitive Impairment)?

我们能否预测遗忘性 MCI（轻度认知障碍）会转变为阿尔茨海默病？

• 发表时间: 2011
• 作者: Naoki Kodama;Satoshi Kasai;Yasuhiro Kawase
• 通讯作者: Yasuhiro Kawase