Predict conversion to Alzheimer's disease from amnestic mild cognitive impairment

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We analyzed the clinical test data of the Alzheimer's dementia (AD) patients and mild cognitive impairment patients whom we were able to follow-up more than two years.Voxel-based Specific Regional analysis system for Alzheimer's Disease (VSRAD) scores of CDR0.5 were 2.29+/-1.39. However, VSRAD scores were higher of 2.71+/-1.53 two years later. This result was the same as CDR1 and CDR2. The parahippocampal gyrus atrophy was every year. In addition, the score of the calculation and the recall of MMSE decreased every year. Furthermore, VSRAD scores were significantly higher at first medical examination in the patients with conversion to AD than in the patients without the conversion, the scores can be used as a predictive marker.