Development of the novel noninvasive bone augmentation technique

新型非侵入性骨增量技术的开发

• 批准号: 21791907
• 负责人: JINNO Yohei
• 金额: $ 2.5万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791907/
• 关键词: 骨増生; 歯科用インプラント; スタチン; 非侵襲; 骨

Within the limitation of our study, we suggest that a single-shot percutaneous injection of fluvastatin with a collagen-α-tricalcium phpsphate (αTCP) composite induces new bone formation in a vertical direction around and under the composite(calvarial bone of rat). However, it is very difficult to obtain new bone on the alveolar bone (rat, dog). Further study is needed for clinical application. (ideal concentration of fluvastatin, investigation of the novel drug delivery system)

在我们的研究范围内，我们建议单次经皮注射氟伐他汀与胶原-α-磷酸三钙（αTCP）复合材料可诱导复合材料（大鼠颅骨）周围和下方垂直方向形成新骨。然而，在牙槽骨上获得新骨非常困难（大鼠、狗）。临床应用需进一步研究。（氟伐他汀理想浓度，新型给药系统的研究）

项目成果

A New Statin Delivery System to Improve the Bone Thickness

一种改善骨厚度的新型他汀类药物输送系统

• 发表时间: 2009
• 作者: Jinno Y;et al
• 通讯作者: et al

The effect of a single remote injection of statin-impregnated poly (lactic-co-glycolic acid)microspheres on osteogenesis around titanium implants in rat tibiae.

单次远程注射他汀类药物浸渍的聚（乳酸-乙醇酸）微球对大鼠胫骨钛植入物周围成骨的影响。

• 发表时间: 2009
• 期刊: Biomaterials 12
• 作者: Masuzaki T;Ayukawa Y;Moriyama Y;Jinno Y;Atsuta I;Ogino Y;Koyano K
• 通讯作者: Koyano K

Vertical bone augmentation with fluvastatin in an injectable delivery system: a rat study

• DOI: 10.1111/j.1600-0501.2008.01665.x
• 发表时间: 2009-08-01
• 期刊: CLINICAL ORAL IMPLANTS RESEARCH
• 影响因子: 4.3
• 作者: Jinno, Yohei;Ayukawa, Yasunori;Koyano, Kiyoshi
• 通讯作者: Koyano, Kiyoshi