Development of the novel noninvasive bone augmentation technique

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Within the limitation of our study, we suggest that a single-shot percutaneous injection of fluvastatin with a collagen-α-tricalcium phpsphate (αTCP) composite induces new bone formation in a vertical direction around and under the composite(calvarial bone of rat). However, it is very difficult to obtain new bone on the alveolar bone (rat, dog). Further study is needed for clinical application. (ideal concentration of fluvastatin, investigation of the novel drug delivery system)