Developmentof biodegradable polymer-calcium phosphate composite as a bone substitute material

可生物降解聚合物-磷酸钙复合材料骨替代材料的研制

• 批准号: 23792233
• 负责人: JINNO Yohei
• 金额: $ 2.33万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23792233/
• 关键词: 骨再生; 骨補填材料; 生体分解性高分子化合物; 骨補填材; スタチン

Calcium phosphate (CaP) biomaterials such as hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), or their composite are commonly used as artificial bone substitute materials. Recent researches indicated that the CaP materials with porous structure exhibited the excellent biocompatibility, however, the drawback of porous CaP materials is that they are extremely brittle and fragile. We developed the novel material with interconnected pores which had CaP nanoparticle-dispersed biodegradable polymer beams. The aim of this study was to evaluate this material as the bone substitute material. In calvaria (rat study), abundant blood vessels and cells infiltration into interconnected pores were observed. In the tibia (rat study), newly-formed bone was observed within the pore of the material. In this study, both PLLA and PCL seemed to be biocompatible, without any inflammatory response. Furthermore, only PLLA displayed the cell infiltration into the pores. New bone formation was observed inside the CaP-dispersed PLLA sponge. These results suggest that the biodegradable polymer-CaP composites is expected to be a potent bone substitute material

磷酸钙(CaP)生物材料，如羟基磷灰石(HA)、β-磷酸三钙(β-TcP)或其复合材料是常用的人工骨替代材料。近年来的研究表明，具有多孔结构的帽子材料表现出良好的生物相容性，但其缺点是极其脆性和脆性。我们开发了具有相互连接的孔的新型材料，该材料具有帽状纳米颗粒分散的可生物降解的聚合物梁。本研究的目的是评价该材料作为骨替代材料的可行性。在颅骨(大鼠研究)中，观察到大量的血管和细胞渗入相互连接的毛孔。在胫骨(大鼠研究)中，在材料的孔洞中观察到新形成的骨。在这项研究中，PLLA和PCL似乎都是生物相容的，没有任何炎症反应。此外，仅PLLA显示细胞渗入毛孔。在帽分散的PLLA海绵内观察到新的骨形成。这些结果表明，可生物降解的聚合物帽复合材料有望成为一种有效的骨替代材料。

项目成果

新しい骨増生術式および骨補填材料の開発-スタチンの局所投与-

新型骨增量技术和骨替代材料的开发-他汀类药物的局部给药-

• 发表时间: 2013
• 作者: Hideo Shimizu;Yohei Jinno;Yasunori Ayukawa;Ikiru Atsuta;Akihiro Furuhashi;Kiyoshi Koyano;神野 洋平
• 通讯作者: 神野 洋平

Evaluations of epithelial sealing and peri-implant epithelial down-growth around "step-type" implants

• DOI: 10.1111/j.1600-0501.2011.02163.x
• 发表时间: 2012-04-01
• 期刊: CLINICAL ORAL IMPLANTS RESEARCH
• 影响因子: 4.3
• 作者: Atsuta, Ikiru;Ayukawa, Yasunori;Koyano, Kiyoshi
• 通讯作者: Koyano, Kiyoshi

Evaluation of biodegradable polymer-calcium phosphate nanoparticle composite as a bone substitute material.

可生物降解聚合物-磷酸钙纳米粒子复合材料作为骨替代材料的评价。

• 发表时间: 2013
• 作者: Shimizu H;Jinno Y;Ayukawa Y;Atsuta I;Furuhashi A;Koyano K
• 通讯作者: Koyano K

生体内分解性高分子化合物を用いた骨組織再生用新規マテリアルの開発

利用可生物降解高分子化合物开发骨组织再生新材料

• 发表时间: 2013
• 作者: Atsuta I;Ayukawa Y;Ogino Y;Moriyama Y;Jinno Y;Koyano K;清水 秀夫,神野 洋平,鮎川 保則,熱田 生,古谷野 潔
• 通讯作者: 清水 秀夫,神野 洋平,鮎川 保則,熱田 生,古谷野 潔