Functionalization of the immediate loading implant by nano-materials and artificial proteins

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Modification of the surfaces of materials, such as titanium, is important in the medical engineering area. We are employing our "carbon nanomaterials" and "motif-programmed artificial proteins" methodology in order to biologically modify the surface of titanium. We have demonstrated that DEX (Dexamethasone)-CNH on titanium attractive candidates four use in a novel drug delivery system. DEX-CNH exhibited sustained release of biologically active DEX in mammalian cells without significant side effects. Furthermore, we successfully created artificial proteins that contain embedding cell attachment and Ti-binding motifs and endowed Ti with cell attachment activity.