The role of Hemokinin-1 in neuropathic pain

Hemokinin-1 在神经性疼痛中的作用

• 批准号: 21791980
• 负责人: MATSUMURA Tomoka
• 金额: $ 2.75万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791980/
• 关键词: 歯科麻酔学; タキキニン; ヘモキニン-1; ミクログリア; 神経因性疼痛

We investigated the role of hemokinin-1 (HK-1), a new member of the tachykinin family, in neuropathic pain. HK-1 is encoded TAC4 gene. In the present study, TAC4 mRNA expression was increased in the cultured microgrial cells which were activated by LPS. That suggests a specific contribution of HK-1 to neuropathic pain.

我们研究了速动素家族的新成员血红素-1 （HK-1）在神经性疼痛中的作用。HK-1编码TAC4基因。在本研究中，培养的微孔细胞经LPS激活后，TAC4 mRNA表达增加。这表明HK-1对神经性疼痛有特殊作用。