The role of Hemokinin-1 in neuropathic pain
The role of Hemokinin-1 in neuropathic pain
批准号:
21791980
负责人:
MATSUMURA Tomoka
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2010
中文摘要
我们研究了速激肽家族的新成员血激素-1(HK-1)在神经病理性疼痛中的作用。HK-1编码TAC4基因。在本研究中,培养的微网状细胞经内毒素激活后,TAC4mRNA的表达增加。这表明HK-1对神经病理性疼痛有特定的作用。
英文摘要
We investigated the role of hemokinin-1 (HK-1), a new member of the tachykinin family, in neuropathic pain. HK-1 is encoded TAC4 gene. In the present study, TAC4 mRNA expression was increased in the cultured microgrial cells which were activated by LPS. That suggests a specific contribution of HK-1 to neuropathic pain.
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