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Effect of the new inhalation anesthetic Desflurane on airway hyperreactivity

Effect of the new inhalation anesthetic Desflurane on airway hyperreactivity
新型吸入麻醉药地氟烷对气道高反应性的影响
批准号:
21592019
负责人:
YAMAKAGE Michiaki
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
This study reveals the mechanism by which the new inhalation anesthetic, desflurane, affects airway heperreactivity. Desflurane relaxed the smooth muscle in ovalbumin-sensitized guinea pigs in vitro, while, conversely, increasing airway resistance in a dose dependent manner in in vivo experiments. These effects could partly be explained by desflurane activation of the tachykinin pathway. This knowledge will contribute to the anesthetic management of patients with hyperresponsive airways.
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Beta-1 selective adrenergic antagonist landiolol and esmolol.....
Beta-1选择性肾上腺素能拮抗剂兰地洛尔和艾司洛尔......
DOI: --
发表时间: 2009
期刊: Heart Lung 38
影响因子: --
作者: [Yamakage M, et al.]
通讯作者: et al.
Different volatile anesthetics have different bronchodilator effects in Ovalbumin-sensitized guinea pigs
不同的挥发性麻醉剂对卵清蛋白致敏的豚鼠具有不同的支气管扩张作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Zhou J, Iwasaki S, Yamauchi M, Yamakage M]
通讯作者: Yamakage M
喫煙・麻酔薬の気管支平滑筋に及ぼす影響
吸烟和麻醉对支气管平滑肌的影响
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Morita M, Sasano H, Azami T, Sasano N, Fujita Y, Ito S, Sugiura T, Sobue K, 白阪哲朗, 山蔭道明]
通讯作者: 山蔭道明
Desflurane induces airway contraction by activating transient receptor potential A1 of C-fibers
地氟醚通过激活C纤维瞬时受体电位A1诱导气道收缩
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yamakage M, Satoh J-I, Kobayashi T, Watanabe H]
通讯作者: Watanabe H
25
    Mechanisms and actions of anesthetics on hyperreactive airway in chronic cigarette-smoking model
    • 批准号:
      18390431
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.6万
    • 财政年份:
      2006
    • 负责人:
      YAMAKAGE Michiaki
    • 依托单位:
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    • 批准号:
      15591648
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.05万
    • 财政年份:
      2003
    • 负责人:
      YAMAKAGE Michiaki
    • 依托单位:
    Investigation of Mechanisms of Volatile Anesthetic Action by the Use of Gene Expression Techniques
    • 批准号:
      12671489
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.18万
    • 财政年份:
      2000
    • 负责人:
      YAMAKAGE Michiaki
    • 依托单位:
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