The clinical study of the boron neutron capture therapy (BNCT) in patients with oral cancer

BNCT前BPA-PET的T/N比值为1.9- 4.0，中子照射量最高为20.1-39.1Gy-Eq，最低为9.12 - 31. 9 Gy-Eq，口腔粘膜照射量为9.03-15. 7 Gy-Eq，正常皮肤表面照射量为2.81 - 7. 64 Gy-Eq，肿瘤缩小效果为CR 2例，PR 5例，PD 1例，生存期4-44个月，不良反应主要为黏膜炎、乏力、脱发、味觉减退、咽部水肿，未见骨髓抑制及颌骨骨髓炎。

The T/N ratio by BPA-PET in front of BNCT is 1.9-4.0.The neutron exposure is up to 20.1-39.1Gy-Eq, and the minimum is 9.12 - 31.9Gy-Eq.The neutron exposure in the oral mucosa is 9.03-15.7Gy-Eq.The normal skin surface is 2.81-7.64Gy-Eq.A reduction effect of tumor is CR two cases, PR five cases, PD one case A survival period after BNCT is 4-44 months.For adverse side effects, mucositis, fatigue, alopecia, impaired taste, and pharyngeal edema were observed.Neither myelosuppression nor osteomyelitis of the jaw bone was observed.Side effect