Experimental study on effect of Rho kinase inhibitors against neurological impairment by environmental toxins

我们主要表明，抑制Rho激酶途径防止甲基汞中毒。2 Rho激酶抑制剂法舒地尔和Y-27632对甲基汞诱导的皮层神经元轴突变性和细胞凋亡有明显的保护作用。法舒地尔对甲基汞中毒模型大鼠周围神经元变性和后肢交叉征有明显的保护作用。此外，Rho激酶抑制剂对暴露于无机汞或鱼藤酮作为负责帕金森病的候选物质的培养的皮层神经元的轴突变性和细胞死亡是有效的。

We mainly show that inhibition of the Rho kinase pathway prevents MeHg-intoxication. 2 Rho kinase inhibitors, Fasudil and Y-27632, significantly protected against axonal degeneration and apoptotic cell death in cultured cortical neuron exposed to MeHg. Fasudil also prevented the neuronal degeneration in peripheral nerves and hind limb crossing sign in MeHg-intoxicated model rats. Furthermore, Rho kinase inhibitors were effective for axonal degeneration and cell death in cultured cortical neuron exposed to inorganic mercury or Rotenone as a candidate substance responsible for Parkinson disease.